My husband had been on lipitor for several years. He thought his symptoms of headache, severe muscle aches, depression were related to just getting older. He is 55 years old. He was beginning to feel like this was the way he was going to have to live the rest of his life. He use to be the life of the party but had got to the point that all he wanted to do was sit in the recliner and rest or sleep. He had even become uninterested in sex. This was one of the main reasons for the depression because he was always very sexual active. It was very depressing that he didn't even want to have sex. He also developed peronies (spelling?) but never even occurred to either one of us that it may be related. His last visit to the doctor (about 3 weeks ago) he mentioned these problems and the doctor told him that he had had several of the similar complaints and they all took lipitor. He told him to stop taking it. He says the improvement in just 3 weeks is amazing. The muscle pain and other symptoms are getting better. He told me that he honestly did not know how much longer he could go on feeling the way he did. We never even thought about researching this drug until the doctor told him to stop taking it. I don't know if the peronies is related but if it is I don't think it is reversable. His doctor is scheduling an appointment with a urologist.