I have used Advair since November, 2003, first 250/50, then 500/50 after a bout with broncitis and phneumonia, and now 150/50 since last winter. My only side affect that I think is a side affect is I have had an increase in blood pressure that caused me to have to take mods, and my eyes have been giving me a fit this past year, draining, mucus, blurred vision at times. except for those I am thankful for the drug. After having severe asthma all of my life, since I was 1 year old and I am now 56, I am a new person all together. Not one asthma attack since the second day after I started using the inhaler. Now I get an albuteral inhaler and it expires before I ever use it.