After having taken various statins for over 8 yrs., my Doc decided my bad cholesterol wasn't coming down fast enough to suit him. A yr. ago, he put me on Vytorin, not the advised dosage, 10/40, but 10/80. I have been suffering from severe panic attacks for over 30 yrs., but they had been bought under control with meds..With the Vytorin, the panic attacks have started again, I am horribly depressed, afraid to go anywhere and panic at the thought of anyone coming to visit. I also have night sweats and muscle pain in my arms so badly it is agony to stretch. Muddled thinking, outbursts against those I love, inability to concentrate, etc. finally caused me to seek my own remedy. After reading of others' experiences with Vytorin, I put 2 and 2 together and stopped taking it on my own, My doc's gonna have a fit when he finds out. But 2 wks. after stopping, my energy levewl has returned the depression is not as bad and the panic attacks are easing. The bad pain is still there; don't know if that will ever go away.....