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I had been taking the brand name Wellbutrin SR (150mg) 2x per day...

Posted at 10:58 AM on Sep 04, 2007 by lstilley, #23374
I had been taking the brand name Wellbutrin SR (150mg) 2x per day. My doctor changed my dose to 200mg 2x a day, and the pharmacy filled it with the generic Bupropion SR. I have noticed my symptoms have been coming back (depression, etc.). I even have had lots of water retention, which makes me feel terrible. I would love to know if anyone has had the same problems with generic vs. the brand name. I know the pharmacy will tell us it is the SAME, but I wish now I would have requested the brand name, even if I had to wait until they shipped it in (they don't have it in stock). Thanks!
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Reply over 2 years ago on Sep 23, 2007 by miamimed, #1996

I take the generic Bupropion SR (get from CVS pharmacy) but haven't noticed those side effects that you mentioned. However I was switching to the generic SR from Wellbutrin XL (which doesn't have a generic version yet) so maybe that was why. Of course generics aren't always exactly the same inactive ingredients so maybe that's causing the problems. Wouldn't it be great if they had to be EXACTLY the same?!?

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Reply over 2 years ago on Oct 17, 2007 by petty5320, #2446

I think I have had the same problem with the generic form. I was doing fine on the Wellbutrin other than the fact that my memory is horrible. I started taking the generic form and after a while noticed that I would become more depressed more often. I took the medication for a month or so then I quit taking it. I waited a few weeks and knew that I should prob keep taking my meds until I spoke with my doctor. For the first few days in the period of starting back, I would feel more depressed then I was when I wasn't on the medication. The depression was nothing too serious, but it was enought to make me take notice. With that being said, I just decided to stay with it and see if the depression went away, and as of today, about 2 weeks back on the medication, I am not feeling depressed after taking my dosage.
I am supposed to go back to my doctor next month but believe I will call back to try for an earlier appointment. After reading this forum, seems that the memory loss is a side effect of the medication.
Has this happened with anyone else?
A

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Reply about 1 year ago on Feb 15, 2008 by lightconquersdark, #4852

I have also experienced the lack of efficacy of generics. I took a Wellbutrin 150 mg pill once and it had a lot of bad and some good. Almost too good (like i was on speed). It was too much drug for me. So 5 days later I took 75 mg of generic Wellbutrin (bupropion) and it just made me sleepy and then irritable and moody. Tried 150 generic and it did the same. There was a substantial difference in the positive effect from just one dose of Wellbutrin XL, which tells me that it is higher quality.
IF there is no difference in quality between generics and name brands, why don't they stop making all name brands, and just make generics? Once the patent runs out, there should be no need whatsoever to continue with the name brand. Why would any customer prefer to pay $150 for a bottle versus $15 for generic of the "same drug." It sounds like someone (drug companies) know what they're doing. And my insurance company used to cover real Zoloft before it went generic. Generic zoloft has also been seen to be inferior.

http://www.npr.org/templates/story/story.php?storyId=15218354&ft=1&f=1007

http://www.msnbc.msn.com/id/21142869/

http://psychcentral.com/blog/archives/2007/10/13/generic-wellbutrin-may-not-perform-as-well-as-original/

www.ConsumerLab.com

www.peoplespharmacy.com

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