I had to take my husband to the ER yesterday due to the side effects of Lisinopril, which he has been taking for 15 years!! His lips were swollen as were his cheeks and he had a heavy rash over many parts of his body. The nurse I spoke to asked if he was having trouble swallowing. He was to call 911 if I didn't get home in time to get him to the ER. The Dr said he was having an allergic reaction to the medication and 20% of people taking it have the reaction of facial swelling which can affect the tongue and/or throat (which can actually close up) no matter how long they have been taking the medication. Until you can get on another bp medicine, have a 50 mg of Benadryl on hand at all times and head for the ER if your face starts to swell or swallowing is a problem.