I starting taking toprol xl 25 mg in Feb 2007. My blood pressure was high because I was experiencing dizziness from a neck injury. I noticed right away muscle weakness around my knees but I thought it was because of my neck and the dizziness. I thought that I was locking my knees more because of afraid of falling. And increased dizziness. But again I assumed it was still from my neck. My neck pain got better but then the muscle weakness got so bad I bought a cane to walk around at work with. One week ago a finally begged the Doc to take me off this medication. I took 1/2 pill for 3 days and then went completely off. I have not started having hot flashes yet, but with the withdrawal I have had a hot flash. My muscle weakness in my legs is better, but not gone. I am still trying to find out how long it will take to get this awful drug out of my system. The doc was convinced it was the drug, and I am scheduled for more tests.