After blaming my intense fatigue, edginess, and lack of interest on possibly Lyme disease, I discovered one evening that one glass of wine seemed to make me tipsy. That led me to realize that I've been feeling this way ever since beginning a regimen of Guaifenex. Have also begun feeling intense stomach cramps. No one else mentions an accelerated effect of alcohol but I believe that much of my total inability to function on the weekends had to do with drinking only a little and ending up hungover. Baaaaaad drug. Me no like.