I had been taking Advair 100/50 for a few years, with little downside until about 6 weeks ago when my asthma became considerably worse. After using albuterol 3-4 times a day, in addition to the Advair, I was getting no relief and a lot of heartburn. I contacted my PCP, who upped my Advair doseage to 250/50. This stuff is awful! I've only been using it for 3 days and I'm stopping it immediately. Every time I use it, I get this flushing sensation throughout my head and cheeks. I've also developed this awful odor, primarily on my hands of all places.