I am 49 years old. I have taken Lisinopril for 8 days. The BP dropped from 175 systolic to 125 in the first two days. Last night I experienced the worst leg cramps ever in my upper thigh and groin area. I frightened my family as I screamed in agony for over an hour. Today I have continuously felt that both legs are going to cramp. I also have arthritis in my knee, which has worsened after needing to immobilize the leg with heat during cramping. My sister suggested the BP medication may have contributed to the cramps, and that's when I found this site. Thank you for all your posts. My meds are going to the police station's collection site tomorrow.