I had Mirena inserted in August 2006 and didn't really notice any side effects at first. Recently I have put all these side effects together and started to research Mirena. I have had breast tenderness with lumps, abdominal pain, acne, depression, anger, and weight gain that I can not get rid of. Against my doctor's wishes I am getting it removed tomorrow morning. I will try to remember to post again when and if I see any results.