I've been on Doxy for 4 months now and Im lucky enough not to have this tingling of the legs and arm but i do get severe nausea, its ridiculous it gets to the point where i cant do anything but lie down and scarf saltine crackers slowly until it gets to my stomach and the Doxy bonds with it. Lately I've been noticing that I'm more tired, but mostly just in the last week and I've been on it for four months. I like to "pad" the pill, eat most of a meal , swallow the pill, and then finish the meal. I hate how inconvenient it is though, no dairy, or vitamins within 2hours, dairy is in a lot more than i once thought. Ive been sick more lately though and i can tell that just missing one day has a drastic effect on my acne :-(