I was prescribed the medicine sulfameth/trimethoprim for a UTI and 1 hour after taking it, I began to itch and noticed red bruises appearing on my arm and back. I also had palpatations. My lips and face began to swell really bad with blisters on my lips and around them. My lips were burning and itching very badly.I also had sores in mouth. I had really bad abdominal pain and difficult breathing.. The next day, I had even more swelling on lips and face and more bruises,vaganal irratations,rashes, severe headache,itching all over body,tongue swelling, throat irratations, bruising continuing all over. I couldn't sleep and was very tired. It has been a week and I am still having some itching, my lips are peeling and still feel very tight as well as bumps on lips and around.The itching and burning on my lips lasted about 5 days as well as most other symptoms. with some lasting longer and all this with taking just 1 pill. After taking this I read so much on this drug and had I read it first, I would have never taken it. I had a reaction to SMZ once and told my doctor that I was allergic to sulfur type drugs and the doctor and pharmacy overlooked it and I was given this anyway. This reaction was much worse than the first. I read so many comments that really helped me and thought maybe I could help someone else. This site is very good.