I have been on Zoloft (150mg) as well as Wellbutrin (300mg) for t...

I have had all the following side effects of Zoloft. Some were 'early' side effects that subsided with use. Others were ongoing.

nausea (Early)
loss of appetite (subsequent weight loss) (Early)
loss of "sexual" appetite (Ongoing)
diarrhea (Early)
constipation (Early)
restlessness; wired feeling) (Early)
insomnia (Early)
tiredness; could sleep all day, if left alone (Ongoing)

But the one that finally made me give up on Zoloft was the night sweats. I found that the sweats usually occurred in the week before and during my menstrual cycle. During this period, I would wake up during the night to find myself and the bedding soaking wet. And the Zoloft sweat had a strange smell -- not like my normal workout sweat.

It's unfortunate that I couldn't live with the night sweats because I really did have pretty good results with Zoloft (for panic disorder).

That's why I'm here now; looking for ways to battle some of these side effects because I really want to try Zoloft again.

I started zoloft about 5 1/2 years ago 50 mg and also have just recently noticed that i am tired and unmotivated and also somewhat sad. the only thing that changed was that I switched to the generic brand.
I am going to call Doctor.

Well it's now March 2008 & hope you have gotten some relief. I'm not tired but wake up at least 3 times a night & have to change clothes dry my hair and lay something dry on the bed so I can lay back now. I have also gained 10 pounds & cannot seem to satified a suger craving like nothing ever before. I take 200 mg of Zoloft. I'm calling my M.D. tomorrow.I'll let you know if I find anything iout that could help.
Rebecca ;)

I was on Zoloft breifly last year for social anxiety disorder and depression. It was horrible. I felt constantly drained like I could just sleep all day, I had night sweats, little or no appetite (which is bad because I'm underweight to begin with), diarrhea and nausea (for about the first month), and one night I woke up crying wanting to kill myself. After that I stopped taking the medication. I couldn't keep taking a medication that made me feel that much worse than I did before. I'm still afraid to try another anti-depressant, so now I'm not taking anything.