Initially I was fine when taking Kadian w/several morphine sulfate tabs for breakthrough pain. Was also taking 5 MG Valium since being treated for chronic nerve neuralgia I've had for over 20 years. Felt wonderful until my prescription for Valium ran out and I did not get refilled. I did not know the Valium was counteracting the negative side effects. When off Valium, horrendous headaches returned with extensive negative side effects,such as tremors, nervousness, voice quivering--that persisted over 1 month off of Valium; well past stage of withdrawal from Valium!