I had been on lisinopril for 3 yrs until a couple of weeks ago. I was taking 10mg in addition to 25mg atenolol(which I have been on for 10yrs). Although I did not notice any serious side effects when I first started on it, it ended up seriously affecting my quality of life. My energy level, which has always been very high, was gradually reduced over the course of the last 3 yrs to a level so low that it was exhausting just to get through the day. I had undergone extensive lab workups to try to figure out what was wrong. I would also have episodes of severe muscle weakness and aches that kept me confined to bed. I was tested for every disease known to man. All came back negative. On top of this, for the first time in my life, I was becoming very depressed and unable to cope with the least little thing to the point where my family became concerned. I also suffered several serious anaphylactic allergic reactions involving serious stomach pains, plummeting blood pressure, pounding heart rate, faintness, swelling of my extremities and shock. I was referred to a specialist and after 4 wks of bloodwork and skin testing, I was incredibly allergic to NOTHING. But I have to carry an epi pen at all times since I don't know when or why a reaction will reoccur. All of this time, I never ever suspected lisinopril as a problem. It was not until one day I was particularly tired and lightheaded and found out that my BP and pulse were way too low (90/50), so I did not take my lisinopril that night (or since then) but only my atenolol. The next day I felt better and within a couple of days incredibly better. My doc has agreed that lisinopril is a problem for me and increased my dose of atenolol to 50mg, which takes care of my BP just fine. Now my energy is returning, my depression has lifted, and I can actually look forward to each day instead of just trying to get through it. I feel like my spark for life is coming back. Like others, I was in a downward spiral and wondered if this is what happens when you turn 50 and if I would ever feel good again. I knew nothing of this website during all of this and wish I had found it long ago. Maybe, just maybe, I would not feel like I missed the last 3yrs of my life.