I have been taking Lisinopril for 4 or 5 years. Two weeks ago I started having severe panic/anxiety attacks. Since I take 3 different medications I started eliminating them from my daily regimen. When I stopped the Lisinopril the anxiety stopped. I had this same problem several years ago with Lopresssor (another BP medicine). It's hard to explain how the anxiety attacks make you feel. You can't sit down, you have to be on tyhe move at all times, and you actually feel like you are going to die. Most horrible feeling I have ever experienced. I was just wondering why it takes so long for Lisinopril to builkd up in ones system before it effects you?