I took 300mg of doxycycline a day for three weeks because I had Lyme Disease. It made my stomach upset but if I found if I ate a few saltine crackers with the pills it took care of the nausea. I also noticed that I became very anxious at times while on the medication. I have been off of the antibiotics now for six days and I still have a painful swollen rash on my hands. I work outside and was exposed to the sun while on Doxy and got the standard sun rash we all know about. What I don't understand is why it is getting worse now, even though I am off the antibiotics. It is so bad that I have been lathering my hands in neospirin and wrapping them with gauze to try and heal them faster, but it doesn't seem to be working.