i had to take Deoxycycline 100mg once a day for a month to treat a skin infection which improved but OMG for the first time in my life I started to feel really WORTHLESS and DEPRESSED I was SAD most of the time and i lost my intrest in the things that i ENJOYED the most , I couldn't concentrate or study and the funny thing is that i did not SUSPECT the medication at all I thouught it was just me you know but when i read what happned to you guys i knew that there must be something because Depression was not listed on Deoxycycline side effects on the FDA site