I've had a horrible dry, hacking cough, both day and night, but especially while I'm laying down trying to sleep. I didn't even think of it being a side effect to Lotrel until I read other users entries. I have only been taking Lotrel for one week, and the cough appeared a day or two after I started taking it. I also have heartburn, which is something I haven't experienced in years! I can only attribute it to the medication since nothing else has changed with my diet.