It seems like everytime I get back on a birth control after getting off it, i react differently. I started on ortho, I felt pregnant, bloated, depressed, acne. Switched to aviane 28 after 2 months, at first, weight loss, clear skin, than cystic pimples in the last week. I stopped early that week, then decided it would be better to finish the pack. So i skipped two of the days and finished the pack. TERRIBLE idea. I've never looked or felt more disgusting in my life and I didn't get a period. I went back on ortho to re regulate myself. Acne, but felt wonderful! unfortunately i stopped b/c the price went up. Felt terrible after stopping dramatic weight loss that i didn't need. Went back on ortho lo, felt weird, very manly. like muscular, and weird puffy face and dark spots on the sides of my face. I lost a pack and decided not to pay $50 again, i;m a college student and bought aviane 28. My skin has never been so clear! I got really tired after taking them so I think next month i'll switch to taking them at night. I don't feel physically healthy yet after a dramatic weight loss after getting off ortho (even though I'm at a healthy weight), but I think i'll continue with them, but take them at night intstead. My advice is don't play around with these hormones. I'm afraid what i'll be like getting off them. I feel safer taking the lower dose though. My sister has been taking this for years, and claims to have no side effects and thinks i'm crazy when I start complaining about birth control.