I was on advair 250/50 for six months initially with no problems. Started it again 6 months later and the side effects began. The first night I experienced a stabbing pain in one wrist.The wrist became painful and weakened. The pain subsided but then there was a throbbing pain in my breast bone. That went on for about 1 month. Stopped the advair and it went away. Unfortunately, I was relying heavily on my rescue inhaler again so I resumed the Advair. This time I experienced neck and shoulder pain. I quit Advair about a month ago. I still have some neck and shoulder pain and swelling. I bought a cleanse from the Garden of Life Company today in an effort to get rid of any Advair that may still be in my system. Hope it works.