I began taking Vytorin and within a week I had terrible muscle and joint pains. Pain in my hips, calves, knees, shoulders, arms. With each day that I took the pill, the pain got more intense to the point where I couldn't walk without limping. After reading multiple entries about this side effect, I immediately stopped taking the drug and the pain is beginning to subside. I absolutely cannot take this drug and will try to find other alternatives to lowering cholesterol as the side-effects in my situation far outweigh the benefits.