This is my second round with Doxycycline for a Staph infection (probably MRSA - the culture isn't back yet); the first round was unpleasant, especially in terms of feelings of heat in my head, wooziness, and rather severe stomach upset and esophagitis due to reflux. I am a Chinese herbalist, and tried going that route with the first bout of the infection (which fortunately is at the skin level), but didn't get much relief so went the route of the 'big guns.' The infection cleared up, more or less, but three weeks later I began to get another new lesion. Grr. Back to Doxy. This second time I've been more proactive, however: Ginger is used in a lot of chinese formulas to help with digestive upset, so I've been taking a couple of pieces of candied ginger as soon as the stomach upset gets going, and hey it works! By the way, I am taking capsules, and I find that lying down on my LEFT side actually helps prevent the reflux pain - the exit of the stomach is on the left side, and since capsules float, lying on my left side keeps the med closer to the exit than the entrance... or so it seems. Whew - I'm glad this stuff is out there, but I'd really like to be done with it - forever....