I have chronic sinusitis and last year I came down with a really bad infection. My Ear Throat Nose Specialist was on vacation so I had to see a "Family Medicine" doctor and he gave me ketek. I had to rush to the emergency room and the doctor there took me off the ketek immediately. I had an EXTREME reaction to it, the scariest effect being the pain in my liver and sudden jaundice (which are the beginning signs of acute liver failure.) There have also been lasting effects, the worst of which being on my heart. My heart rate has always been below average, and ever since the reaction my heart rate has been recorded as abnormally fast.