Trazodone was probably the most effective anti-depressant I was ever prescribed. Since I ceased taking Trazodone Hydrochloride I have gained weight. I'd been taking the anti-depressant for about 6 years; before Trazodone I was taking Seroxat and before that Prozac. I no longer take anti-depressants. I have been off Trazodone for 3 months now and I've seen a gradual rise in my weight and I am now about 6 kilos heavier than I was in August. I am a male of 52 years.