I'm 48 and my doctor has given me three months supply of Loestrin 24Fe and a prescription for a year. I'm diabetic and have trouble with my blood sugar control with Glucophage XR. She said it wouldn't interact with any of my meds, but when I looked it up, it said it would reduce the effectiveness of Glucophage. After reading all your posts, I'm throwing these and the prescription in the trash. I'd rather have erotic periods than have to start using insulin or die from a stroke. I'm already overweight and depressed so I don't think I need any more problems. Thanks for all your testimonials ladies.