After about 1/2 hour of using Flonase for the first time, I felt a burning or tearing-type feeling in my left chest more toward the shoulder area. Then after a couple of days use I felt an irritation in the shoulder joint and this subsequently traveled to my rib cage. After about a week's worth of use, I felt a burning-like sensation in a small area on my lateral lower leg. I stopped using the Flonase and after about 4 days, the sensations subsided.