I also want to get off of the seroquel but it seems almost impossible. I take 300mg.at bedtime. I was on 400mgs. It keeps me pretty stable. I am wondering if you got off of the seroquel yet and what did you get to substitute? I think Ambein CR helps me sleep better than seroquel. Of course I was taking seroquel 200mg. trying to decrease off of it and added a neurontin 300mgs.at bedtime as introducing it as a mood stabilizer. I don't think it works too well so I discontinued the neurontin and stopped taking the ambien cr. It took a few days to get back to normal but ambien works so well. I am afraid to take it with seroquel. I don't want to get addicted to that method. Sleep is most important to a bipolar. Why do we fight our medications? I am having serious side effects and I don't know if it is the zetia I take at bedtime with the seroquel? I am discontinuing the zetia at bedtime for a while to see if it helps the gastrointestinal problems I have been having.