My experience with Lotrel has been just horrible. In September 2000, I was prescribed Lotrel 5-10. For one week I used it and began stroking out. I was in the hospital for 5 hours with a very bad headache. I found out months from an MRI that I had a stroke. I have a headache everyday even when my blood pressure is down. I learned about this website December 12, 2007. I would have posted this sooner.