I was diagnosed with Dysthmia in April 07 and the doc prescribed Seroquel (25mg) and Topamax (25mg) I took them for about a week and felt spacey, like I was floating or something. I was scared to drive to work for fear that I would zone out and get in a car accident. So I stopped taking both after a week. Then I started again with both meds (same dosages) this Oct. I'm still on them and haven't experienced any weight gain. If anything, I'm losing weight...but since weight loss is a side effect of Topamax, it's probably countering the appetite gain effects of the Seroquel. My sex life is completely gone. I'm becoming emotionless and I feel like a zombie. Even on 25 mg I fall asleep within 25-30 minutes of taking the Seroquel. I'm so drowsy in the morning and it takes me a long time to get moving in the morning. I am always tired and seem to be fatigued most of the time. Once in awhile I have extreme energy bursts. My mood is more stable, but I plan to begin weaning myself off soon because I want my love life back. Also I have frequent muscle pains on the side of my stomach. Not sure where its coming from...I feel like I've been beat up.