I suffer from chronic gastritis, not diarrhea, just inflammation, have taken this for sinus and upper respiritary infection. 250mg four times a day. It has helped me with alleviating the constant constipation I suffer from, but it has really made my gastritis worse, to the extent that I am having throat irritation through acid reflux now! Also felt shaky and weak about an hour after each dose, and so very tired, overwhelmingly tired and weak. Have completed the course, but would not wish to take again. I can't have Penicillin drugs because of allergy. VERY IMPORTANT, I was on a statin pill (Lipitor) and was told my the pharmacist to watch for muscle problems, after first day on EM my leg muscles seized up and were cramping badly, I stopped the statin for the duration of the antibiotic. If you are on statins, beware.