I've been on it since last July and take 3- 75 mg a day. I take one late afternoon around 4pm and 2 at bed around 10 pm. After having terrible pain down both legs and lower back pain for the last 20 years it has been so good not to have that pain everyday. I have gained 10 lbs and that is the worse side effect I've had that's been long term. At first I felt drunk and could hardly walk but after a couple of weeks all that went away. I sleep so much better and have a lot more energy than I've had for years. I love this drug except for the weight gain. Guess I'll have to use the treadmill more often!