2 major side effects. I find myself waking up startled and wide awake about an hour and a half after falling to sleep. I usually go back to sleep, but awake again in another couple of hours. This waking is not associated with urination either. before Januvia, I would sleep most of the night around 8-9 hours, with maybe one bathroom break necessary. Now, a full night's sleep is rare. Also, I have been dreaming more vividly and intense. The dreams are much more disturbing, and I have more anxiety in my dreams than I do in regular life. All this started immediately after starting Januvia, and I have been taking 100mg daily for 3 weeks. My endocrinologist does not seem to think there is a connection, but I know there is! I have also had the advertised stuffy nose and slight sore throat. The blood sugars have changed pretty dramatically along with the Avandamet I am taking.