The hair loss is the worse thing. I have also noticed a change in my skin in additional to extremely soft toe nails. At this time I am off Warfarin - (developed mysterious blood clots) so was recommended to take it for six months. The hair loss occurred after 3 months of treatment. However, I have a friend who has taken it for years with no side effects. As long as I stayed the course with my dosage (10mg) my INR was on mark. Not sure what to expect now that I am off of it but I will say I am extremely paranoid about every feeling I have in my legs.