Zoloft was working for my depression (very slowly though--took about a month or more), was helping with my lethargy (that worked a lot quicker -- within a week or two), also worked for my panic attacks. I didn't even mention to my doctor that I had panic attacks, but after I started taking the Zoloft for depression I noticed that the panic attacks virtually disappeared. Problem is, I stopped taking the Zoloft without consulting with my doctor (big mistake), and lately I have noticed very severe headaches every day that don't go away with Excederin (usually works for me). I also notice some level of paranoia (although not extremely serious). Zoloft saved my life and my job, but I would not advise stopping cold turkey without consulting with a physician.