Have been on Doxycycline Hyclate on and off for the last 6 months for acne treatment. I hadn't been enjoying the way the pills made me feel so I had neglected to use my last bottle of sixty (100mg 2Xdaily) until my acne flared up this past holiday season. On Friday the 18th of January I went to workout, came home and cooked myself a big breakfast, and then decided to lie down for a nap an hour later. The bottle was next to my bed and I hadn't taken my dose for the day, but I had just eaten a big meal so I wasn't too worried. I took the pill w/o water and lied down. BIG MISTAKE. I woke from my nap about 90 minutes later with the most intense burning sensation I've ever felt. It was just below my rip cage in the center of my body (I think it's the flap between the esophagus and the stomach) and now it's Tue. the 22nd of January and it still hurts every time I swallow and especially when I eat food. It sounds like I'm not alone with this problem and I would love to hear from somebody if this is temporary or what their Doctor told them to do. Thanks for your help.