I've been on Effexor for at least 6 months. At first it really helped with my depression and anger issues and it sort of curbed my appetite so I was really happy. Then that stopped, I gained at least 20 lbs if not more, I have recently had severe stomach pains and headaches. Also, don't ever drink on it. Even when I have 2 glasses of wine I turn into a crazy person alcoholic even and drink so much (almost obsessive) that I black out and usually loose control of my ability to hold in urine and pee the bed. I was NEVER like this before, EVER. I've stopped taking it and yes the rage is back, but at least I'm not peeing the bed.