I have been taking 160milligrams a day for almost a year. After a serious accident in '99 that left me Partially Paralyzed and been on all kinds of pain meds...hate them all. Especially the Oxycontin. The Methadone has been a life saver. I am a productive, well-adjusted member of society....instead of a junky needing another OC. Take it like your supposed to Kiddies and the rest of us won't have the magnifying glass on us for no reason. Eat right and you won't "Gain Weight or be constipate." Just like regular Folk.... Duh.