I I have been on this pill for over a year. I am a 45 year old mother of two and have had absolutely no negative effects. I also have an anxiety condition and have noticed no increase in symptoms. The short periods are great. My greatest complaint on this pill, as was on all the others I tried is, no sex drive. I have tried so many. The one designed to promote clear skin, made me breakout. No pill is going to be perfect for every woman. You need to be your own advocate and try and try different pills until you find the one that works for you. I tried the patch..I had an eternal period, but, some women love it. If anyone has found a form of birth control, (other than IUD) that brings back sex drive...PLEASE let me know!!