I took Effexor XR for 6 months. The first week I couldn't sleep but that was the only side-effect, that is, until I quit. I decided to quit when I noticed that there was no difference in my mood and when I missed a day I would get a strange feeling. "Brain-shivers" is what they're described as. Almost like a drunk and wobbly feeling. After I stopped taking it the "shivers" lasted about 2 weeks and the first few days were the WORST! I went to the Dr. to get gradually get off but after taking the first one (37.5mg) and still felt the same - cold turkey is was! I wouldn't take it again. It didn't help and the withdrawal was terrible.