Hi I am Paul I am a 53 year old male and have been taking Advair 250/50 for just over 4 years. I am so happy I found this site. In the past 4 years I have had increasing pain in my legs, muscles, back, hoariness in the throat, can't even talk half the time, its been impossible to loose weight half the time I feel like I am swollen up like a balloon. And also have heart palpitations and rapid pulse even when I am sitting still I have gotten to the point where I have to walk with a cane and can hardly work anymore, so I stopped taking the Advair and switched back to Albuterol inhaler hopefully I have not done any unreversable damage to myself by taking the Advair. I HAVE DEEMED IT TO BE BAD MEDICINE!