I was prescribed Remeron (Avanza in Australia) for a neurotransmitter deficiency that was causing "depression-like" symptoms including lack of energy, low libido, poor sleep, pessimistic thoughts, brain fog etc etc. I really wanted to give Remeron a good try because most other anti-ds that I've taken have an even worse effect on my sleep. Remeron was good taken at 30mg to help me sleep (I found 15mg knocked me out even more and was ridiculously tired the next day). I however progressively slipped into depression over a period of 3 weeks where I had zero energy, complete apathy and was really irritable to the point of having a massive blow up with family and girlfriend. I was told these effects would lessen in time and I would feel "lighter" and "better" - This didn't happen at 4 weeks and although I should keep going at a higher dose before knowing for sure if this medication doesn't work for me, I read on this page that feelings of irritability and agitation continue while on the med - This is cause enough for me to not be on this medication. Within 48 hours of stopping, I feel better already! Remeron - apparently works for most but not for me.