i too had a reaction to z-pack. started feeling very fatigued. urine became very dark. then headaches, then vomiting. blood pressure shot up. went to doc who ran blood work. liver enzimes very high. went to ER after about 4 days of not eating, sleeping, etc. spent 3 days in the hospital and it was determined i had liver inflammation (hepititis) from the z-pack. today is the first day i have been feeling better in over a week.