The posting by mlbalinge on February 19th fits my reaction exactly. I have also never had any allergic reactions to medications before. Within two minutes I had a strange feeling inside my mouth, in ten minutes my face felt like it was on fire, extremely red and breathing became very difficult. My wife called an ambulance immediately and I was given Benadryl on the way to the ER. My wife and brother told me my face and lips were swollen twice their normal size. My blood pressure was 40/30 and I did think I was dying. In the ER, I remember shaking and feeling cold. I was given Benadryl and steroids in the ER and then admitted to the hospital to ICU. I was released the following day. After this experience, I will never take Avelox again.