I am so glad I found this site. I thought I must be crazy. My doctor and I are still looking for something I can take for depression and GAD, so he decided I should try Effexor XR. This is an EVIL drug! I only started out on 37.5 mg, but I can't get past the second day on it. My headache is so bad I feel like my brain is going to explode! Not to mention the palpitations and insomnia. I thought it may be something else so I stopped and after a couple of days my headache eased off. I guess I must be a glutton for punishment because I decided to try it again several days later to see if it was the Effexor. Same side effects all over again. I will not be taking this drug again. If I feel this horrible at 37.5 mgs. I can't imagine what would happen at a higher dose. This stuff should be removed from the market!