This is my third time on Topamax...and I am weaning myself off again...The first time I loved it! I don't drink pop so I could care less about the taste issues. I suffered some tingling so I took Magnesium for that, some fatigue, low blood pressure, etc. But, due to a rapid weight loss (I was already small) and low blood pressure my doctors took me off. Then when I put some weight back on and the severe migraines persisted, I was put back on. Then, lots of tingling, dry eyes, fatigue, NO weight loss (apparently it only works the first time for loss) and weird vision disturbances and feeling dopey and not being able to talk, teach to type. So, I stopped again. Well, I can't live with the headaches, so on again. Well, it's been over 2 and a half years total now and I am just now beginning to see the real effects of this nasty medicine. I have been "sick" for over a year and no doc (10 total) can figure out what's wrong!!!! I have been researching a lot and come to the conclusion that it very well may be long-term use Topamax effects...45 lb. weight GAIN in a year and a half, constant nausea, severe fatigue, skin rashes, female infections non-stop, dry skin, lips and hair, dental issues, muscle and joint pain, pins and needles in feet, eye twitching, constant cold hands and feet, metallic smell to hands, body odor,insomnia the list goes on and on...Some of these I just noticed when my neuro (who thinks Topamax is the only cure!) upped my dosage again due to daily headaches and I started researching. I am currently weaning off of 150 mg. (100 at night and 50 in the am). I have been on up to 250 mg before. Although it used to help my headaches, the side effects are just too much to bare.