This is my 3rd day on Bactrim. The side effects are horrible. I am taking 1 pill 2x per day for an ear infection. I am experiencing extreme fatigue, gastrointestinal upset, agitation and insomnia. I don't know how much longer I can put up with these side effects. I feel like staying in bed all day and just taking a shower and getting dressed makes me exhausted. I am 23 years old and thought I was really sick, so I ran a search on Bactrim. I would not recommend this drug to people. Ask your doctor for something else instead. The side effects with this drug are pretty bad.