I took Levaquin for a sinus infection and by the 3rd day I had such terrible muscle and tendon aches that I couldn't sleep. I seemed to get a little relief from standing up. I thought I had hurt my back--never thinking it was the medication. Although the medication was working well for the infection, I could not stand the pain and had been taking Tylenol#3 for it. After stopping the Levaquin, the muscle and tendon pain subsided, but it has been 6 weeks and I still get sharp leg pains. I took 5 of the 10 day prescription. I then finished up with Amoxicillin 500mg for the infection.