my brother is taking advair for COPD. he is also on blood pressur...

my brother is taking advair for COPD. he is also on blood pressure medicine and a medicine to stop smoking. he has been having terrible insomnia for many months now. also. several times when he's driving, he's suddenly become so tired, he has to pull over. it happened again recently in the middle of the afternoon and he had an accident. he says just before the wave of fatigue comes over him, he seems to have some severe allergic reaction with sinus drainage. has anyone else ever had any of these experiences? this seems incredibly scary.