i started Zoloft on 2/7 (25mg), on 2/22 i started the full dose (50mg). i couldn't sense any changes during the time i was on 1/2, but as soon as i started the full dose the following occurred: very tired/groggy, especially in the afternoons, at bedtime i was very sleepy and on weekends with no alarm slept 12 hours every night! (my normal is 7-8 hours a night). i am not as regular as i usually am. i started feeling itchy on my whole body a few times, and a few days ago my palms started itching like mad. i visited my doctor yesterday and we decided to go back to 1/2 of the dose for a week and then stop - i started on Wellbutrin today, we'll see how that goes.